Banca de DEFESA: ARIMAR CHAGAS DE ALMEIDA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : ARIMAR CHAGAS DE ALMEIDA
DATA : 20/02/2019
HORA: 14:00
LOCAL: Proppit
TÍTULO:

 

ANTIMALARIAL ACTIVITY OF Kalanchoe pinnata ON Plasmodium berghi IN EXPERIMENTAL MODEL IN VIVO

PALAVRAS-CHAVES:

Plasmodium berghei, Kalanchoe pinnata, malaria.

PÁGINAS: 59
GRANDE ÁREA: Ciências Biológicas
ÁREA: Biologia Geral
RESUMO:

Malaria is an infectious disease caused by a microscopic parasite, which infects about 200 million people a year. It presents as a cyclic fever followed by chills, intense sweating, nausea, vomiting, pallor and physical weakness, which intensify according to the level of parasitemia and the species of Plasmodium that infect individuals. Despite being a worldwide problem, malaria does not present a homogeneous geographic distribution, being its higher incidence in tropical and subtropical regions such as the Legal Amazon in Brazil. Currently, a range of drugs used to treat malaria has become inefficient because some strains of Plasmodium vivax and Plasmodium falciparum already have multiple resistance to these drugs. In this context, it is necessary to seek new therapeutic alternatives for the treatment of malaria, such as plants. Among the thousands of plant species, Kalanchoe pinnata is a plant that presents indicative of hypotensive, anti-inflammatory and antirheumatic effect. Thus, the possibility of researches with the extract of Kalanchoe pinnata, widely used in the North of Brazil for the treatment of inflammations, wounds, cutaneous ulcers, abscesses, analgesia and also antiparasitic activity against Leishmania amazonensis. In view of this, the present study aims to evaluate the antimalarial activity of the hydroalcoholic extract of Kalanchoe pinnata in an in vivo model of malaria using BALB/c mice infected with Plasmodium berghei. To this end, the hydroalcoholic extract of Kalanchoe pinnata was evaluated for its toxicity and effects (suppression of parasite density, animals survival time, plasma glucose levels, liver and renal function and haematological parameters) in the treatment of BALB/c mice infected with Plasmodium berghei. Thus, K. pinnata extract was safe for treatment with the studied doses, showing similar effect of the standard drug artemisinin, such as increased survival time, parasitic suppression, control of glycemic levels and renal and hepatological functions, besides haematological parameters. Thus, it has been shown that this extract presents itself as an effective alternative for the treatment of malaria.

MEMBROS DA BANCA:
Presidente - 1834385 - WALDINEY PIRES MORAES
Externo ao Programa - 1496075 - BRUNO ALEXANDRE DA SILVA
Externo à Instituição - JOSAFA GONÇALVES BARRETO - UFPA