Banca de DEFESA: ÉDEN BRUNO SOUSA DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : ÉDEN BRUNO SOUSA DA SILVA
DATA : 27/05/2019
HORA: 14:30
LOCAL: Sala 117 - Unidade Amazônia
TÍTULO:

Evaluation Of Anti-Inflammatory, Antiproliferative And Production Of Reactive Oxygen Species Of The Ethanolic Extract Of Cyperus Articulatus L. (Cyperaceae)

PALAVRAS-CHAVES:

Inflammation. medicinal plant. oxigen-reactive species. nitric oxide. arginase. antiproliferative. cancer.

PÁGINAS: 90
GRANDE ÁREA: Ciências Biológicas
ÁREA: Farmacologia
SUBÁREA: Etnofarmacologia
RESUMO:

Priprioca (Cyperus articulatus L.) is a medicinal plant traditionally used against inflammation. Studies on the essential oil of this species have led to the identification of many terpene compounds. Little is known about the use of the solid residues generated after the extraction of the essential oil of this species. This work aimed to investigate the chemical composition and to evaluate the anti-inflammatory, antioxidant and antiproliferative activity in vitro of the ethanolic extract of solid residues generated from the extraction of the essential oil of Cyperus articulatus L., in peritoneal macrophages of mice and cell lines tumor cells. The following methodology was used to achieve these objectives: chromatographic analysis, cell viability, nitric oxide production, prostaglandins type 2, interleukin 1 beta, tumor necrosis factor alpha and reactive oxygen species, arginase activity, antiproliferative activity. Results: The chemical composition analysis indicated the presence of monoterpenes, sesquiterpenes and especially sesquiterpene ketones as major constituents. The results showed that the treatment with ethanolic extract of Cyperus articulatus L. decreases the production of reactive species of oxygen, nitric oxide, prostaglandins type 2, interleukin 1 beta, tumor necrosis factor alpha, activity of the arginase enzyme and proliferation of cancer cells. The ethanolic extract of Cyperus articulatus L. also did not demonstrate cytotoxicity at concentrations of 12.5, 25 and 50 μg/mL. The results indicated that the extract of Cyperus articulatus L. exerts antioxidant, antiproliferative and anti-inflammatory activity in experimental models in vitro.

MEMBROS DA BANCA:
Presidente - 1562643 - MAXWELL BARBOSA DE SANTANA
Externo ao Programa - 1414049 - FLAVIA GARCEZ DA SILVA
Externo ao Programa - 1765839 - DEBORA KONO TAKETA MOREIRA