Banca de DEFESA: HIAGO SOUSA PINHEIRO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : HIAGO SOUSA PINHEIRO
DATA : 22/08/2019
HORA: 14:00
LOCAL: Auditório do NTB
TÍTULO:

ANTIMICROBIAN USE AND ACUTE KIDNEY INJURY OCCURRENCE INPATIENTS IN A WEST HOSPITAL OF PARÁ

PALAVRAS-CHAVES:

Pharmacovigilance, antibiotic therapy, adverse drug reaction, nephrotoxicity

PÁGINAS: 77
GRANDE ÁREA: Ciências Biológicas
ÁREA: Farmacologia
SUBÁREA: Toxicologia
RESUMO:

Pharmacovigilance is the science of detecting, evaluating, understanding, preventing adverse effects or any drug-related problems. Its main objective is to ensure patient safety and rational use. In studies on adverse drug reactions, among the classes most likely to cause harm to organisms are antimicrobials. This class of drugs may induce nephrotoxicity and cause complications in patients. One of the most common problems with high incidence rates in the hospital setting is acute kidney injury (AKI), a complication that affects most patients and can lead to kidney failure or even death. The aim of this study was to evaluate the incidence of acute kidney injury in patients hospitalized under exposure to nephrotoxic antimicrobials at the Baixo Amazonas Regional Hospital, as well as to describe the demographic and clinical profile of the patients, to verify the variation of serum creatinine during the use of antimicrobials with potential to promote nephrotoxicity and determine plasma vancomycin concentrations. The study was a prospective, observational cohort of hospitalized patients between October 2018 and January 2019. Patients were assessed for inclusion and exclusion criteria on the fifth day of hospitalization. As sources for data collection were used the medical records, prescriptions and results of laboratory tests available in the patient records. Included participants were interviewed and followed for identification of AKI development according to the KDIGO guidelines and plasma quantification of vancomycin concentrations was also performed in patients using this antibiotic. A total of 70 patients were evaluated, with a mean age of 52.49 ± 20.31 years, most of them male (64.29%; n = 45) and coming from the cancer clinic (34.29%; n = 24). Of the patients followed, 48.57% (n = 34) developed AKI and 20.59% (n = 7) reached stage 3 AKI. 20.00% (n = 14) of the patients died, of which seven had developed AKI. An average of 10.26 ± 2.9 drugs prescribed per patient was identified. The most prescribed antimicrobials were ceftriaxone, cefepime and piperacillin/tazobactam. Of the patients using amphotericin B for infectious treatments, 100% (n = 2) presented AKI and 60% (n = 6) of the patients receiving vancomycin antibiotic were diagnosed with AKI. The results of plasma vancomycin concentrations showed that patients who developed AKI during vancomycin use had concentration values ranging from 3 μg/mL to 15.9 μg/mL, most with values below the minimum recommended concentration (10 -20 µg/mL). Understanding the factors associated with the occurrence of AKI in patients admitted to the hospital under exposure to nephrotoxic antimicrobials is of great relevance, as it serves as an aid for the early identification of drug-induced renal dysfunction, providing prevention and appropriate management of these patients, It also reinforces the importance of the pharmacist's role in caring for critically ill patients.

MEMBROS DA BANCA:
Presidente - 1834385 - WALDINEY PIRES MORAES
Externa ao Programa - 2171514 - TANIA MARA PIRES MORAES
Externa ao Programa - 1414049 - FLAVIA GARCEZ DA SILVA
Externo ao Programa - 1496075 - BRUNO ALEXANDRE DA SILVA