Banca de DEFESA: SUELEN MARIA SANTOS DE SOUZA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : SUELEN MARIA SANTOS DE SOUZA
DATA : 07/02/2020
HORA: 15:00
LOCAL: Sala 332 - Unidade Amazônia
TÍTULO:

RELATIONSHIP OF THE HEPATIC AND RENAL PROFILE WITH THE MERCURIAL EXPOSURE IN INDIVIDUALS OF THE MUNICIPALITY OF SANTARÉM, PARÁ

PALAVRAS-CHAVES:

Mercury; Exposition; Hepatic profile; Profile renal.

PÁGINAS: 70
GRANDE ÁREA: Ciências da Saúde
ÁREA: Saúde Coletiva
SUBÁREA: Epidemiologia
RESUMO:

Mercury (Hg) is a heavy metal that is present throughout the earth's crust and among all contaminating metals, is found in the highest level of toxicity due to its characteristics of biomagnification and bioaccumulation at different trophic levels, including humans. Studies described in literature, have already proved that the main target organs for the toxic action of Hg in humans are: brain, lung, digestive tract, renal and hepatic system. Taking into account that other studies have already proven that the population of the Amazon region is environmentally exposed to this metal, the general objective of this study is to evaluate the relationship between liver and kidney profile with mercurial exposure in individuals from the municipality of Santarém, Pará. It is a field research with an observational, descriptive and quantitative approach and was carried out from January 2017 to July 2019, in several locations in the municipality of Santarém, being divided into urban area, plateau and region of rivers (Amazon and Tapajós Rivers). This work is linked to the research protocol approved by the CEP of the “State University of Pará” -UEPA, under the opinion of 1,127,108 and met all the requirements established in the resolution 466/2012. To obtain the data, a semi-structured questionnaire was applied, and blood was collected. The blood collection was performed by venipuncture and 10 ml of sample was collected from each volunteer. This amount was divided into two portions, 5 ml for the measurement of Total Mercury (HgT) and 5 ml for the measurement of biochemicals necessary to trace the hepatic and renal profile. The measurement of HgT was carried out in the Bioprospecting and Molecular Biology Laboratory of the Federal University of Western Pará - UFOPA and the enzymatic and biochemical measurements were carried out in the Clinical Analysis Laboratory of the “Esperança Foundation”. The data obtained through the questionnaire were used to trace the epidemiological profile of the individuals through a descriptive analysis using frequency charts. For the quantitative variables, measures of central tendency and dispersion (mean, median and standard deviation) were calculated using the Excel program, a component of Microsoft Office (version 2013). Subsequently, the analyzes were tabulated and organized in tables according to the reference values for each test and by community. Then, Pearson's Shi-square test was applied to observe the homogeneity in the sample distribution in relation to the results (normal and altered) of values for both sexes, both for normal and altered values, of renal and hepatic markers, as for Hg levels. Inference analysis was performed after checking normality using the Shapiro-Wilk test. Four possible relationships were analyzed: Hg levels and frequency of fish consumption, Hg levels and gender, Hg levels and serum levels of renal markers, Hg levels and serum levels of hepatic markers. The statistical tests were performed using the STATA 7.0 software, with a significance level of 5%. The results show that the biochemical profile of the kidney and liver did not show a statistically significant relationship with mercurial exposure; of the 236 individuals who participated in this study, 78.4% (N = 185) are exposed to Hg; communities on the banks of the Tapajós River have higher HgT concentrations than communities on the Amazon River; The individuals who consume fish with high frequency, represented 84.3% of the analyzed sample, this group had the highest levels of HgT, an average of 108.4 μg / L. Considering that renal (urea and creatinine) and hepatic markers (TGO and TGP) used in this study, are proven to be sensitive ones for kidney and liver damage, respectively, in the analyzed sample, no individuals with a biochemical profile consistent with kidney and liver damage were found. However, an important question emerges from these data: this exposed population needs to be monitored and clinically needs guidance until it is elucidated how much Hg concentration the body can handle, until it responds with signs and symptoms and / or with biochemical changes.

MEMBROS DA BANCA:
Presidente - 1562643 - MAXWELL BARBOSA DE SANTANA
Interno - 1836832 - RUY BESSA LOPES
Externa ao Programa - 1414049 - FLAVIA GARCEZ DA SILVA