Banca de DEFESA: MARLEN DO CARMO SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : MARLEN DO CARMO SILVA
DATA : 28/01/2021
HORA: 14:30
LOCAL: Ambiente Virtual - https://meet.google.com/gkk-hxcj-rkp
TÍTULO:

EVALUATION OF NEUROLOGICAL SYMPTOMS IN DOGS AFFECTED BY KINOMOSIS VIRUS TREATED WITH NONI METHANOLIC EXTRACT (Morinda citrifolia Linn)

PALAVRAS-CHAVES:

Morinda citrifolia, antiviral activity, distemper

PÁGINAS: 67
GRANDE ÁREA: Ciências Agrárias
ÁREA: Medicina Veterinária
RESUMO:

From the infectious diseases with the most common neurological signs in dogs, canine distemper is undoubtedly the most routinely observed in the medical clinic of small animals. The canine distemper is caused by a Morbillivirus of the Paramyxoviridae family, it has high morbidity and mortality, where in most cases, only a symptomatic support is established for the animal, since there is no specific treatment for the disease. The several studies report the antiviral, immunomodulatory, anti-inflammatory, antioxidant and neuroprotective activities of noni (Morinda citrifolia) led to the objective of this study was to evaluate the efficacy of treatment with dried methanolic extract of noni fruits in dogs with neurological symptoms affected by distemper virus. The fruits were harvested from community orchards in Belterra municipality, State of Pará. The preliminary chromatographic profile of the extract produced by thin layer chromatography (TLC) which discovered the presence of condensed tannins, terpenes, flavonoids and coumarin compared to the reference standards colorations. The dogs and mices used for the present study was approved by the ethics committee under numbers 1120180087/2019 and 1120190047/2020. For the symptomatological evaluation, seventeen dogs were divided as follows: G1 (control group, using allopathic treatment - 9 animals), G2 (treated with 1000mg of the extract - 8 animals). The oral administration of noni methanolic extract at a dose of 1000mg/animal proved to be moderately efficient, in the remission of neurological signs caused by distemper if compared to the control group. The extract results for acute toxicity in mice did not reveal intoxication signs, as well as there was no significant change in the treated dogs urea and creatinine biochemical tests, based on the references markers of Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT), suggesting that the extract has no nephro or hepatotoxic effects. At the end of the experiment, two animals from G1 survived, while in G2 there were 6 survivors.

MEMBROS DA BANCA:
Presidente - 1661684 - KELLY CHRISTINA FERREIRA CASTRO
Interno - 1562643 - MAXWELL BARBOSA DE SANTANA
Interna - 1967452 - ADRIANA CAROPREZO MORINI