Banca de DEFESA: JANDER MARCUS CIRINO LOPES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : JANDER MARCUS CIRINO LOPES
DATE: 31/03/2023
TIME: 14:00
LOCAL: Ambiente Virtual link: https://join.skype.com/d2i3Jp1LfKJk
TITLE:

EVALUATION OF ANTIDEPRESSIVE AND ANXIOLYTIC ACTIVITY OF ESSENTIAL OIL FROM Cyperus articulatus L.

KEY WORDS:

Mental disorders. Depression. Anxiety. Essential oil of Cyperus articulatus L.

PAGES: 62
BIG AREA: Ciências Biológicas
AREA: Farmacologia
SUBÁREA: Neuropsicofarmacologia
SUMMARY:

The mental disorders that most affect humanity are depression and anxiety, where depression is described as depressed and persistent mood, since anxiety refers to emotional and physiological manifestations such as tensions or exaggerated fears. Pharmacological treatments available on the market today have a variety of adverse effects, therefore, the project seeks new therapeutic alternatives that are effective in the treatment of depression and anxiety, that cause less adverse effects, at low cost. The objective of this research was to evaluate the antidepressant and anxiolytic activity of the essential oil of Cyperus articulatus L., in vivo in experimental models. The collection and chemical characterization were carried out, and the plant material came from the Experimental Farm of the Federal University of Western Pará (UFOPA). For the experimental tests, female mice of the Swiss strain, multiparous, non-pregnant and healthy were used. The chemical characterization of OECA showed as major compounds: α-copaene (2.87%), β-selinene (4.00%), caryophyllene oxide (2.99%), mustacone (21.43%), cyperotundone (3.86%), cis-tujopsenal (7.70%), cyclocolorenone (11.94%). In the evaluation of acute oral toxicity, it was observed that the acute toxic dose is greater than 2000 mg/kg, classifying it in category 5 according to the criteria of the protocol adopted by OECD-423/2001. Thus, the results of the tests carried out showed that the essential oil of Cyperus articulatus L., significantly reduced the parameter of immobility time in the forced swimming test at the concentration 400mg/kg by 64.60% (44.6 ± 3.36) , when compared to the control group, indicating an antidepressant-like effect. Cyperus articulatus L. essential oil significantly increased the time spent in the open arms of the elevated plus maze at a concentration of 400 mg/Kg (151.8 ± 8.90), indicating an anxiolytic effect. In view of this, it can be inferred that the essential oil of Cyperus articulatus L., can contribute to the search for new approaches and therapeutic alternatives and for the treatment of depression and anxiety, but further studies are necessary for a more in-depth investigation of its antidepressant effect. and anxiolytic.

COMMITTEE MEMBERS:
Presidente - 1562643 - MAXWELL BARBOSA DE SANTANA
Interna - ***.147.002-** - ALANNA DO SOCORRO LIMA DA SILVA - UFRA
Externa ao Programa - 1995687 - ELDRA CARVALHO DA SILVA - UFOPAExterna à Instituição - SANDRA LAYSE FERREIRA SARRAZIN - UFOPA