Banca de QUALIFICAÇÃO: PATRÍCIA GABRIELLY DA SILVA PIRES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : PATRÍCIA GABRIELLY DA SILVA PIRES
DATE: 22/11/2021
TIME: 10:00
LOCAL: via Google meet
TITLE:

Anti-edematogenica and antiniceptive activity of Pectis elongata Kunth essential oil

KEY WORDS:

Esssential oil, Pectis elongata, anti-edematogenic activity, anti-nocicptive activity

PAGES: 53
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

The present work aims to investigate the anti-inflammatory and analgesic properties of the essential oil of Pectis elongata Kunth; an aromatic herb belonging to the Asteraceae family, widely used by traditional communities to treat pain and inflammation. It has in its composition two major components, citral isomers (neral and geranial), monoterpenes with anti-inflammatory and analgesic action already described in the literature. The main hypothesis investigated in this work is that the essential oil obtained from P. elongata can serve as an alternative to standard therapy for the treatment of pain and inflammation, since these classes of conventional drugs can have many adverse reactions leading to non-adherence to the treatment by the patients. The identification of the neral and geranial components, present in other plant species, as responsible for their analgesic and anti-inflammatory properties established in the literature, is a strong evidence that Pectis elongata, a native and abundant species in the Amazon, could serve as a solution to problem presented. This hypothesis will be investigated through in vivo tests of paw edema induced by λ-carrageenan, to identify anti-inflammatory action and formalin test, where antinociceptive action (pain) is verified. Rats (n=30) of the Wistar lineage will be used for the paw edema test and mice (n=30) of the Swiss lineage will be used for the formalin test, which will be divided into 6 groups with 5 animals each. The results will be statistically analyzed, in both tests, by analysis of variance ANOVA followed by Tukey test, with confidence intervals of 5%. Values of p ≤ 0.05 will be considered statistically significant.

BANKING MEMBERS:
Interno - 1562643 - MAXWELL BARBOSA DE SANTANA
Presidente - 1190556 - RICARDO BEZERRA DE OLIVEIRA
Interna - 2171514 - TANIA MARA PIRES MORAES