Banca de QUALIFICAÇÃO: ALCIENE FERREIRA DA SILVA VIANA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ALCIENE FERREIRA DA SILVA VIANA
DATE: 23/11/2021
TIME: 10:00
LOCAL: via Google meet
TITLE:

Phytochemical characterization and biological activity of cutitis Pouteria macrophylla (Lam.)

KEY WORDS:

Antioxidant. Inflammation. Pouteria macrophylla. cutitis

PAGES: 41
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

The species Pouteria macrophylla, popularly known as cutite, has medicinal use for several pathologies, however, few researches show its biological activity, being only reported the potential antioxidant activity of this Amazonian fruit. The importance of plant foods has been increasingly highlighted and, among their properties, the antioxidant activity of chemical constituents of these foods has assumed an important role. The main purpose of this study is to evaluate the antioxidant capacity and anti-inflammatory activity of the extract from fruits and leaves of Pouteria macrophylla. For this, the collection of botanical material for the preparation of leaf and fruit extracts was carried out at the Tapajós Unit of the Federal University of western Pará, Campus Santarém. The phytochemical characterization of the fruit and leaf extracts of Pouteria macrophylla will be carried out through the quantification of phenolic compounds, flavonoids and tannins. The evaluation of the antioxidant capacity of the extracts will be carried out using the ABTS and DPPH methods. The anti-inflammatory activity will be performed in cultures of macrophages stimulated with LPS and IFN-γ, through the analysis of cell viability and dosage of inflammatory mediators nitric oxide, TNF-α, IL-1B and PGE2 in order to contribute to the knowledge of the species and possible use as a pharmacological tool for the treatment of inflammatory diseases through more effective drugs with fewer adverse effects.

BANKING MEMBERS:
Externa à Instituição - DEBORA KONO TAKETA MOREIRA
Interno - 1562643 - MAXWELL BARBOSA DE SANTANA
Presidente - 2171514 - TANIA MARA PIRES MORAES