Banca de DEFESA: HERMAN ASCENÇÃO SILVA NUNES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : HERMAN ASCENÇÃO SILVA NUNES
DATE: 04/11/2022
TIME: 14:30
LOCAL: sala no Google meet: meet.google.com/vyz-dqcm-pqh
TITLE:

NANOEMULSION CONTAINING ESSENTIAL OIL FROM Pectis elongata Kunth: ANTIMICROBIAL, ANTI-INFLAMMATORY AND STIMULANT POTENTIAL SKIN WOUND HEALING PROCESS

KEY WORDS:

Wounds, essential oil, nanotechnology, healing, citral.

PAGES: 73
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUBÁREA: Farmacognosia
SUMMARY:

Pectis elongata Kunth, Asteracea, is an herbaceous plant, known in Northern Brazil as "wild cuminho", "lemon rosemary", "cuminho" or "wild rosemary". It is a species rich in essential oil, whose major constituent is citral, a component with recognized antifungal, anti-inflammatory, analgesic, sedative, antibacterial properties, among others. In this project, our proposal is to evaluate the efficiency of the nanoemulsification process of P. elongata essential oil on the retention of its main volatile constituents and antimicrobial, anti-inflammatory and stimulating properties of the healing process of skin wounds. For this, in the first step, already carried out, the essential oil of P. elongata was found by hydrodistillation and the nanoemulsification process carried out by the low-energy method. The essential oil yield was determined in 1% w/v. The chemical composition of the free and nanoemulsified oil was provided by gas chromatography coupled with mass spectrometry, which pointed out citral as the major constituent for both as analyzed: free (92,5%) and nanoemulsified oil (94,8%, 96,8% e 82%, respectively). In the next step, we will carry out the analysis of the chemical composition of the nanoemulsion at times 30 and 60 days after preparation. The antimicrobial potential of the essential oil and nanoemulsified will be evaluated by agar disk-diffusion and broth microdilution methods, the anti-inflammatory potential will be evaluated by the carrageenan-induced paw edema test and the stimulating potential of the healing process evaluated on skin wounds induced by surgical incision. We hope that the P. elongata essential oil nanoemulsification process will be effective both in maintaining its chemical properties and in preventing the growth of microorganisms, modulating the inflammatory response and promoting the healing process of skin wounds.

COMMITTEE MEMBERS:
Presidente - ***.421.662-** - SANDRA LAYSE FERREIRA SARRAZIN - UFPA
Interno - 1190556 - RICARDO BEZERRA DE OLIVEIRA
Interna - 2139720 - KARIANE MENDES NUNES
Externo à Instituição - TIAGO SANTOS SILVEIRA - UEPA