Banca de DEFESA: CARLA SOUSA DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : CARLA SOUSA DA SILVA
DATE: 06/06/2023
TIME: 09:30
LOCAL: Sala virtual https://meet.google.com/njm-dcdk-ssz
TITLE:

BIOMARKERS OF LIVER CHANGE/INJURY AND INFLAMMATION IN PATIENTS HOSPITALIZED WITH COVID-19 AT THE ONLY REFERENCE HOSPITAL IN BAIXO AMAZONAS, WEST PARÁ, BRAZIL: A LONGITUDINAL RETROSPECTIVE STUDY

KEY WORDS:

Biomarkers; COVID-19; Liver; Inflammation; SARS-CoV-2

PAGES: 89
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

Introduction: COVID-19 is a complex and multisystem disease. This study aims to investigate, over time, changes in markers of liver changes/injury and inflammation in relation to clinical outcome in COVID-19 in a cohort of hospitalized patients in the Baixo Amazonas, Pará, Brazil. This is a cohort study involving patients diagnosed with COVID-19 who were hospitalized at the Hospital Regional do Baixo Amazonas, Pará, Brazil, between March 25, 2020 and March 29, 2022. The research was approved by the Ethics Committee and Research at the Universidade Federal do Oeste do Pará. Results: 397 patients were included in the study. Most were men (66.5%), aged 60 years or older, and more than half had died (51.9%). Systemic Arterial Hypertension, Diabetes Mellitus and obesity were the most common comorbidities. Respiratory and neurological signs and symptoms were manifested in hospitalized patients. In the longitudinal follow-up of liver markers, a significant difference was found for AST on D14, with a higher median in the death group. As for the other biochemical markers, a significant difference was found for CRP on D1 and D7, D-dimer on D1, SaO2 on D21. Among the hematological markers, lymphopenia was observed throughout the follow-up, with the death group having the most altered values. Conclusion: Patients who died during hospitalization or developed a more severe clinical picture for COVID-19 showed more significant changes in liver and inflammatory biomarkers. These biomarkers should serve as a guide for monitoring the evolution of these patients.

COMMITTEE MEMBERS:
Presidente - 1071690 - LUANA LORENA SILVA RODRIGUES
Interno - 1243405 - THALIS FERREIRA DOS SANTOS
Externa à Instituição - Nádia Vicência do Nascimento Martins - UEPA
Externa à Instituição - LUCIANE ALMEIDA AMADO LEON - Fiocruz - RJ