Banca de DEFESA: IZABELE PEREIRA DA SILVA LOPES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : IZABELE PEREIRA DA SILVA LOPES
DATE: 10/11/2023
TIME: 10:00
LOCAL: BMT 1 – SALA 327 – UFOPA TAPAJÓS
TITLE:

NEUROBEHAVIORAL AND HISTOPATHOLOGICAL EVALUATION OF MICE EXPOSED TO SUBCHRONIC DOSES OF NANOEMULSION CONTAINING ESSENTIAL OIL OF P. elongata KUNTH (VERBENACEAE)

KEY WORDS:

Pectis elongata, essential oil, nanoemulsion, neurobehavior, neurotoxicity, histopathology

PAGES: 67
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUBÁREA: Análise Toxicológica
SUMMARY:

Essential oils are volatile compounds derived from the secondary metabolism of plants. These substances have applications in different industrial sectors, including pharmaceuticals. Its healing properties are strictly linked to its chemical composition, however, because they are highly volatile and unstable at room temperature, the chemical compounds present in essential oils can easily undergo oxidative degradation, isomerization and polymerization. One way to preserve their physicochemical characteristics is to involve them in nanostructured systems, such as nanoemulsions. These, in turn, are formulation characterized as dispersed systems, kinetically and thermodynamically stable, formed by two immiscible liquids, stabilized by a surface-active agent, and which have droplets of nanometric size in the internal phase (between 20 and 200nm). Although they have shown to be promising candidates in the protection, transport and targeted delivery of bioactive substances, nanoemulsions must be evaluated regarding the probability of promoting toxicity when applied in biological systems. In the present study, our objective is to evaluate the possible neurotoxic effects of the nanoemulsion containing P. elongata essential oil, performing in vivo experiments, through the behavioral evaluation of mice exposed to subchronic doses of the nanoemulsion, in addition to the evaluation of weight loss and histopathological analysis; the latter to verify possible changes in the morphology of cells in the Central Nervous System.

COMMITTEE MEMBERS:
Presidente - ***.421.662-** - SANDRA LAYSE FERREIRA SARRAZIN - UFPA
Interna - 2171514 - TANIA MARA PIRES MORAES
Interno - 1562643 - MAXWELL BARBOSA DE SANTANA
Externa à Instituição - ELENN SUZANY PEREIRA ARANHA